I think you're right about the title being essentially ambiguous. I just thought it was ironic, that everyone is in pairs or groups of three, except for Cicero, who is both isolated and (imho, of course) the one man who probably does deserve the title in 43.

If so, did you notice that Mere Smith wrote this episode?

I did not! And I never paid attention to who wrote what episodes of Angel -- but of course Angel was full or horrible parent-child relationships, wasn't it?